General Information:

Id: 6,508
Diseases: Metabolic
Rattus norvegicus
inner medulla membrane of kidney
article
Reference: Marples D et al.(1995) Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla J. Clin. Invest. 95: 1838-1845 [PMID: 7535800]

Interaction Information:

Comment Chronic lithium therapy often causes nephrogenic diabetes insipidus.
Formal Description
Interaction-ID: 61819

drug/chemical compound

Lithium

increases_activity of

disease

Diabetes insipidus, nephrogenic

Drugbank entries Show/Hide entries for Lithium
Comment Lithium treatment reduced AQP2 protein expression. Thirsting for 48 h during lithium treatment, caused a increase in urine osmolality and a increase in AQP2 protein expression.
Formal Description
Interaction-ID: 61821

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

AQP2

in inner medulla membrane of kidney
Drugbank entries Show/Hide entries for Lithium