General Information:

Id: 6,504
Diseases: Metabolic
Rattus norvegicus
cerebellar granule cell
article
Reference: Chen RW and Chuang DM(1999) Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity J. Biol. Chem. 274: 6039-6042 [PMID: 10037682]

Interaction Information:

Comment Treatment with LiCl decreases the level of proapoptotic p53 mRNA and protein.
Formal Description
Interaction-ID: 61788

drug/chemical compound

Lithium

decreases_expression of

gene/protein

TP53

Drugbank entries Show/Hide entries for Lithium or TP53
Comment Treatment with LiCl decreases the level of proapoptotic BAX mRNA and protein.
Formal Description
Interaction-ID: 61789

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

BAX

Drugbank entries Show/Hide entries for Lithium
Comment Treatment with LiCl increases the level of cytoprotective BCL2 mRNA and protein.
Formal Description
Interaction-ID: 61790

drug/chemical compound

Lithium

increases_quantity of

gene/protein

BCL2

Drugbank entries Show/Hide entries for Lithium or BCL2
Comment Treatment with LiCl decreases the level of proapoptotic BAX mRNA and protein.
Formal Description
Interaction-ID: 61791

drug/chemical compound

Lithium

decreases_expression of

gene/protein

BAX

Drugbank entries Show/Hide entries for Lithium
Comment Treatment with LiCl decreases the level of proapoptotic p53 mRNA and protein.
Formal Description
Interaction-ID: 61792

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

TP53

Drugbank entries Show/Hide entries for Lithium or TP53
Comment Treatment with LiCl increases the level of cytoprotective BCL2 mRNA and protein.
Formal Description
Interaction-ID: 61793

drug/chemical compound

Lithium

increases_expression of

gene/protein

BCL2

Drugbank entries Show/Hide entries for Lithium or BCL2