General Information:

Id: 6,492 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
review
Reference: Quiroz JA et al.(2004) Molecular effects of lithium Mol. Interv. 5: 259-272 [PMID: 15471909]

Interaction Information:

Comment Lithium inhibits some enzymes through competition for Magnesium as a cofactor, since lithium has a ionic radius that is similar to that of magnesium.
Formal Description
Interaction-ID: 61634

drug/chemical compound

Lithium

affects_quantity of

drug/chemical compound

Mg2+

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Comment Lithium inhibits inositol polyphosphate 1-phosphatase (IPPase), inositol monophosphate phosphatase (IMPase), fructose 1,6-bisphosphatase (FBPase), and bisphosphate nucleotidase (BPNase). All these enzymes contain a conserved amino acid sequence motif, Asp-Pro-(Ile or Leu)-Asp-(Gly or Ser)-(Thr or Ser), and have a common core tertiary structure that binds metal ions, usually Mg2+.
Formal Description
Interaction-ID: 61636

drug/chemical compound

Lithium

decreases_activity of

gene/protein

INPP1

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Comment Lithium inhibits inositol polyphosphate 1-phosphatase (IPPase), inositol monophosphate phosphatase (IMPase), fructose 1,6-bisphosphatase (FBPase), and bisphosphate nucleotidase (BPNase). All these enzymes contain a conserved amino acid sequence motif, Asp-Pro-(Ile or Leu)-Asp-(Gly or Ser)-(Thr or Ser), and have a common core tertiary structure that binds metal ions, usually Mg2+.
Formal Description
Interaction-ID: 61637

drug/chemical compound

Lithium

decreases_activity of

gene/protein

IMPase

Drugbank entries Show/Hide entries for Lithium
Comment Lithium inhibits inositol polyphosphate 1-phosphatase (IPPase), inositol monophosphate phosphatase (IMPase), fructose 1,6-bisphosphatase (FBPase), and bisphosphate nucleotidase (BPNase). All these enzymes contain a conserved amino acid sequence motif, Asp-Pro-(Ile or Leu)-Asp-(Gly or Ser)-(Thr or Ser), and have a common core tertiary structure that binds metal ions, usually Mg2+.
Formal Description
Interaction-ID: 61638

drug/chemical compound

Lithium

decreases_activity of

gene/protein

FBP

Drugbank entries Show/Hide entries for Lithium
Comment Lithium inhibits inositol polyphosphate 1-phosphatase (IPPase), inositol monophosphate phosphatase (IMPase), fructose 1,6-bisphosphatase (FBPase), and bisphosphate nucleotidase (BPNase). All these enzymes contain a conserved amino acid sequence motif, Asp-Pro-(Ile or Leu)-Asp-(Gly or Ser)-(Thr or Ser), and have a common core tertiary structure that binds metal ions, usually Mg2+.
Formal Description
Interaction-ID: 61639

drug/chemical compound

Lithium

decreases_activity of

gene/protein

BPNT1

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Comment Lithium inhibits the metabolic enzymes phosphoglucomutase and glycogen synthase kinase-3.
Formal Description
Interaction-ID: 61640

drug/chemical compound

Lithium

decreases_activity of

gene/protein

PGM

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Comment Lithium inhibits the metabolic enzymes phosphoglucomutase and glycogen synthase kinase-3 beta.
Formal Description
Interaction-ID: 61659

drug/chemical compound

Lithium

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for Lithium or GSK3B
Comment IMPase and IPPase are enzymes involved in recycling and de novo synthesis of inositol, which is a necessary component of the phosphoinositol signaling pathway. Lithium inhibits both enzymes which results in a decrease of myo-inositol and an accumulation of inositol-1-monophosphate.
Formal Description
Interaction-ID: 61667

drug/chemical compound

Lithium

decreases_quantity of

drug/chemical compound

Inositol

Drugbank entries Show/Hide entries for Lithium
Comment BDNF levels increases in the brains of rats treated chronically with lithium.
Formal Description
Interaction-ID: 61742

drug/chemical compound

Lithium

increases_quantity of

gene/protein

BDNF

in the brain; via inducing cAMP-mediated signaling leading to activation of CREB-induced gene transcription
Drugbank entries Show/Hide entries for Lithium
Comment Lithium activates the ERK/MAP kinase cascade in human neuroblastoma SH-SY5Y cells.
Formal Description
Interaction-ID: 61770

drug/chemical compound

Lithium

increases_activity of

process

MAPK cascade

in human neuroblastoma SH-SY5Y cells and in limbic areas of rat brain
Drugbank entries Show/Hide entries for Lithium
Comment Addition of lithium produces an increase in the activation of ribosomal S6 kinase and CREB.
Formal Description
Interaction-ID: 61772

drug/chemical compound

Lithium

increases_activity of

gene/protein

RPS6K

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Comment Addition of lithium produces an increase in the activation of ribosomal S6 kinase and CREB. CREB plays a major role in long-term neuroplasticity.
Formal Description
Interaction-ID: 61773

drug/chemical compound

Lithium

increases_activity of

gene/protein

CREB1

via inducing cAMP-mediated signaling and MAPK/ERK cascade
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Comment Lithium modulates cAMP-mediated signaling. The physiologic effects of cAMP is mediated by activation of protein kinase A which activates the transcription factor CREB, important for long-term neuroplasticity.
Formal Description
Interaction-ID: 61810

drug/chemical compound

Lithium

affects_activity of

Drugbank entries Show/Hide entries for Lithium
Comment Phosphatidylinositol-mediated signaling affects the expression of SMIT (SLC5A3), a high affinity myoinositol transport system. Activity and mRNA expression of SMIT is downregulated in cultured astrocytes after treatment with lithium.
Formal Description
Interaction-ID: 61814

drug/chemical compound

Lithium

decreases_activity of

gene/protein

SLC5A3

Drugbank entries Show/Hide entries for Lithium
Comment Phosphatidylinositol-mediated signaling affects the expression of SMIT (SLC5A3), a high affinity myoinositol transport system. Activity and mRNA expression of SMIT is downregulated in cultured astrocytes after treatment with lithium.
Formal Description
Interaction-ID: 61815

drug/chemical compound

Lithium

decreases_expression of

gene/protein

SLC5A3

Drugbank entries Show/Hide entries for Lithium
Comment IMPase and IPPase are enzymes involved in recycling and de novo synthesis of inositol, which is a necessary component of the phosphoinositol signaling pathway. Lithium inhibits both enzymes which results in a decrease of myo-inositol and an accumulation of inositol-1-monophosphate.
Formal Description
Interaction-ID: 62196

drug/chemical compound

Lithium

increases_quantity of

drug/chemical compound

Inositol 1-phosphate

Drugbank entries Show/Hide entries for Lithium
Comment Lithium modulates cAMP-mediated signaling. The physiologic effects of cAMP is mediated by activation of protein kinase A which activates the transcription factor CREB, important for long-term neuroplasticity.
Formal Description
Interaction-ID: 62972

drug/chemical compound

Lithium

affects_activity of

drug/chemical compound

Adenylate cyclase

Drugbank entries Show/Hide entries for Lithium