General Information:

Id: 6,492 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
review
Reference: Quiroz JA et al.(2004) Molecular effects of lithium Mol. Interv. 5: 259-272 [PMID: 15471909]

Interaction Information:

Comment Lithium inhibits inositol polyphosphate 1-phosphatase (IPPase), inositol monophosphate phosphatase (IMPase), fructose 1,6-bisphosphatase (FBPase), and bisphosphate nucleotidase (BPNase). All these enzymes contain a conserved amino acid sequence motif, Asp-Pro-(Ile or Leu)-Asp-(Gly or Ser)-(Thr or Ser), and have a common core tertiary structure that binds metal ions, usually Mg2+.
Formal Description
Interaction-ID: 61636

drug/chemical compound

Lithium

decreases_activity of

gene/protein

INPP1

Drugbank entries Show/Hide entries for Lithium or INPP1