General Information:

Id: 6,491
Diseases: Bipolar disorder
Metabolic
Homo sapiens
HEK-293 cell
article
Reference: Borsotto M et al.(2007) PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder Pharmacogenomics J. 7: 123-132 [PMID: 16733521]

Interaction Information:

Comment The brain- and neuron-specific gene PPP2R2C is associated to bipolar disorder.
Formal Description
Interaction-ID: 61586

gene/protein

PPP2R2C

affects_activity of

disease

Bipolar disorder

Comment The brain-and neuron-specific gene PPP2R2C is associated to bipolar disorder.
Formal Description
Interaction-ID: 61587

gene/protein

PPP2R2C

is_expressed_in

tissue/cell line

brain

Comment The brain- and neuron-specific gene PPP2R2C is associated to bipolar disorder.
Formal Description
Interaction-ID: 61588

gene/protein

PPP2R2C

is_expressed_in

tissue/cell line

neuron

Comment PPP2R2C interacts with the KCNQ2 potassium channel.
Formal Description
Interaction-ID: 61589

gene/protein

PPP2R2C

interacts (colocalizes) with

gene/protein

KCNQ2

in HEK-293 cells and in a brain-specific cDNA library
Drugbank entries Show/Hide entries for KCNQ2
Comment KCNQ2, the gene encoding a potassium channel protein, is associated with bipolar disorder.
Formal Description
Interaction-ID: 61592

gene/protein

KCNQ2

affects_activity of

disease

Bipolar disorder

Drugbank entries Show/Hide entries for KCNQ2
Comment Lithium inhibits the GSK3beta kinase activity.
Formal Description
Interaction-ID: 61600

drug/chemical compound

Lithium

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for Lithium or GSK3B
Comment GSK3beta kinase is capable to phosphorylate the KCNQ2 channel.
Formal Description
Interaction-ID: 61607

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

KCNQ2

Drugbank entries Show/Hide entries for GSK3B or KCNQ2
Comment GSK3beta kinase is capable to phosphorylate the KCNQ2 channel. When phosphorylated, the KCNQ2 channel becomes inactive, while dephosphorylation increases its activity.
Formal Description
Interaction-ID: 61608

gene/protein

GSK3B

decreases_activity of

gene/protein

KCNQ2

Drugbank entries Show/Hide entries for GSK3B or KCNQ2
Comment PP2A-Bgamma increases the KCNQ2wt current amplitude shown by electrophysiological experiments. This suggests that PP2A, via its Bgamma-regulatory subunit, stimulates the dephosphorylation of KCNQ2wt.
Formal Description
Interaction-ID: 61614

gene/protein

PPP2R2C

increases_activity of

gene/protein

KCNQ2

Drugbank entries Show/Hide entries for KCNQ2
Comment PP2A-Bgamma increases the KCNQ2wt current amplitude shown by electrophysiological experiments. This suggests that PP2A-Bgamma stimulates the dephosphorylation of KCNQ2wt.
Formal Description
Interaction-ID: 61615

gene/protein

PPP2R2C

decreases_phosphorylation of

gene/protein

KCNQ2

Drugbank entries Show/Hide entries for KCNQ2
Comment KCNQ2 splice variants (3H2, 3H9) differ from native channels by their shortened C-terminal sequences. They exert a dominant-negative effect on KCNQ2 wild-type channel activity.
Formal Description
Interaction-ID: 61633

mRNA/protein variant

KCNQ2-3H2

decreases_activity of

gene/protein

KCNQ2

Drugbank entries Show/Hide entries for KCNQ2
Comment After lithium treatment KCNQ2wt current is increased.
Formal Description
Interaction-ID: 63413

drug/chemical compound

Lithium

increases_activity of

gene/protein

KCNQ2

via inhibiting GSK3beta activity
Drugbank entries Show/Hide entries for Lithium or KCNQ2
Comment KCNQ2, the gene encoding a potassium channel protein, is associated with bipolar disorder.
Formal Description
Interaction-ID: 63754

gene/protein

KCNQ2

increases_activity of

process

ion transport

Drugbank entries Show/Hide entries for KCNQ2