General Information:
Id: | 6,491 |
Diseases: |
Bipolar disorder
Metabolic |
Homo sapiens | |
HEK-293 cell | |
article | |
Reference: | Borsotto M et al.(2007) PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder Pharmacogenomics J. 7: 123-132 [PMID: 16733521] |
Interaction Information:
Comment | The brain- and neuron-specific gene PPP2R2C is associated to bipolar disorder. |
Formal Description Interaction-ID: 61586 |
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Comment | The brain-and neuron-specific gene PPP2R2C is associated to bipolar disorder. |
Formal Description Interaction-ID: 61587 |
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Comment | The brain- and neuron-specific gene PPP2R2C is associated to bipolar disorder. |
Formal Description Interaction-ID: 61588 |
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Comment | PPP2R2C interacts with the KCNQ2 potassium channel. |
Formal Description Interaction-ID: 61589 |
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Drugbank entries | Show/Hide entries for KCNQ2 |
Comment | KCNQ2, the gene encoding a potassium channel protein, is associated with bipolar disorder. |
Formal Description Interaction-ID: 61592 |
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Drugbank entries | Show/Hide entries for KCNQ2 |
Comment | Lithium inhibits the GSK3beta kinase activity. |
Formal Description Interaction-ID: 61600 |
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Drugbank entries | Show/Hide entries for Lithium or GSK3B |
Comment | GSK3beta kinase is capable to phosphorylate the KCNQ2 channel. |
Formal Description Interaction-ID: 61607 |
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Drugbank entries | Show/Hide entries for GSK3B or KCNQ2 |
Comment | GSK3beta kinase is capable to phosphorylate the KCNQ2 channel. When phosphorylated, the KCNQ2 channel becomes inactive, while dephosphorylation increases its activity. |
Formal Description Interaction-ID: 61608 |
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Drugbank entries | Show/Hide entries for GSK3B or KCNQ2 |
Comment | PP2A-Bgamma increases the KCNQ2wt current amplitude shown by electrophysiological experiments. This suggests that PP2A, via its Bgamma-regulatory subunit, stimulates the dephosphorylation of KCNQ2wt. |
Formal Description Interaction-ID: 61614 |
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Drugbank entries | Show/Hide entries for KCNQ2 |
Comment | PP2A-Bgamma increases the KCNQ2wt current amplitude shown by electrophysiological experiments. This suggests that PP2A-Bgamma stimulates the dephosphorylation of KCNQ2wt. |
Formal Description Interaction-ID: 61615 |
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Drugbank entries | Show/Hide entries for KCNQ2 |
Comment | KCNQ2 splice variants (3H2, 3H9) differ from native channels by their shortened C-terminal sequences. They exert a dominant-negative effect on KCNQ2 wild-type channel activity. |
Formal Description Interaction-ID: 61633 |
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Drugbank entries | Show/Hide entries for KCNQ2 |
Comment | After lithium treatment KCNQ2wt current is increased. |
Formal Description Interaction-ID: 63413 |
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Drugbank entries | Show/Hide entries for Lithium or KCNQ2 |
Comment | KCNQ2, the gene encoding a potassium channel protein, is associated with bipolar disorder. |
Formal Description Interaction-ID: 63754 |
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Drugbank entries | Show/Hide entries for KCNQ2 |