General Information:

Id: 6,488 (click here to show other Interactions for entry)
Diseases: Metabolic
Rattus norvegicus
Reference: Bosetti F et al.(2002) Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E(2) concentration in rat brain Mol. Psychiatry 7: 845-850 [PMID: 12232777]

Interaction Information:

Comment Lithium decreases brain PGE2 concentration, a bioactive product of arachidonic acid, formed via the COX reaction. This indicates that COX-2 activity is downregulated by lithium.
Formal Description
Interaction-ID: 61785

drug/chemical compound


decreases_quantity of

drug/chemical compound

Prostaglandin E2

in brain
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