General Information:

Id: 6,487
Diseases: Lung disease
Metabolic
Rattus norvegicus
cecal ligation and puncture (CLP)-induced tissue injury model
article/cited
Reference: Albayrak A et al.(2013) Protective effects of lithium: a new look at an old drug with potential antioxidative and anti-inflammatory effects in an animal model of sepsis Int. Immunopharmacol. 16: 35-40 [PMID: 23542012]

Interaction Information:

Comment Acute respiratory distress syndrome occurs as a systemic response to sepsis. (cited information)
Formal Description
Interaction-ID: 61546

phenotype

sepsis

increases_activity of

Comment Lithium has been used to treat bipolar disorder. (cited information)
Formal Description
Interaction-ID: 61547

drug/chemical compound

Lithium

decreases_activity of

disease

Bipolar disorder

Drugbank entries Show/Hide entries for Lithium
Comment Lithium results in an increase in the Th2 cytokines IL-4 and IL-10, along with a decrease in the Th1 cytokines IFNc and IL-2. (cited information)
Formal Description
Interaction-ID: 61548

drug/chemical compound

Lithium

increases_quantity of

gene/protein

IL10

Drugbank entries Show/Hide entries for Lithium
Comment Lithium results in an increase in the Th2 cytokines IL-4 and IL-10, along with a decrease in the Th1 cytokines IFNc and IL-2. (cited information)
Formal Description
Interaction-ID: 61550

drug/chemical compound

Lithium

increases_quantity of

gene/protein

IL4

Drugbank entries Show/Hide entries for Lithium
Comment Lithium results in an increase in the Th2 cytokines IL-4 and IL-10, along with a decrease in the Th1 cytokines IFNc and IL-2 (cited information).
Formal Description
Interaction-ID: 61551

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

IL2

Drugbank entries Show/Hide entries for Lithium or IL2
Comment Treatment with lithium reduced the LPS-induced secretion of tumor necrosis factor-alpha, interleukin-1beta, PGE2, and nitric oxide. (cited information)
Formal Description
Interaction-ID: 61553

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

TNF

in rat primary glial cells
Drugbank entries Show/Hide entries for Lithium or TNF
Comment Treatment with lithium reduced the LPS-induced secretion of tumor necrosis factor-alpha, interleukin-1beta, PGE2, and nitric oxide. (cited information)
Formal Description
Interaction-ID: 61554

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

IL1B

in rat primary glial cells
Drugbank entries Show/Hide entries for Lithium or IL1B
Comment Treatment with lithium reduced the LPS-induced secretion of tumor necrosis factor-alpha, interleukin-1beta, PGE2, and nitric oxide. (cited information)
Formal Description
Interaction-ID: 61555

drug/chemical compound

Lithium

decreases_quantity of

drug/chemical compound

Prostaglandin E2

in rat primary glial cells
Drugbank entries Show/Hide entries for Lithium
Comment Treatment with lithium reduced the LPS-induced secretion of tumor necrosis factor-alpha, interleukin-1beta, PGE2, and nitric oxide. (cited information)
Formal Description
Interaction-ID: 61556

drug/chemical compound

Lithium

decreases_quantity of

drug/chemical compound

NO

in rat primary glial cells
Drugbank entries Show/Hide entries for Lithium
Comment Lithium significantly reduced the expression of cyclooxygenase-2 and inducible nitric oxide synthase, indicating that lithium exhibits a potent anti-inflammatory effect. (cited information)
Formal Description
Interaction-ID: 61557

drug/chemical compound

Lithium

decreases_expression of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for Lithium or PTGS2
Comment Lithium significantly reduced the expression of cyclooxygenase-2 and inducible nitric oxide synthase, indicating that lithium exhibits a potent anti-inflammatory effect. (cited information)
Formal Description
Interaction-ID: 61558

drug/chemical compound

Lithium

decreases_expression of

gene/protein

NOS2

Drugbank entries Show/Hide entries for Lithium or NOS2
Comment The serum levels of the pro-inflammatory cytokines, TNF-alpha, IL-6, and IL-1beta decreased after administration of lithium in rats with CLP-induced lung injury.
Formal Description
Interaction-ID: 61559

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

TNF

in serum; if expression has been upregulated in a CLP-induced lung injury model
Drugbank entries Show/Hide entries for Lithium or TNF
Comment The serum levels of the pro-inflammatory cytokines, TNF-alpha, IL-6, and IL-1beta decreased after administration of lithium in rats with CLP-induced lung injury.
Formal Description
Interaction-ID: 61560

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

IL1B

in serum; if expression has been upregulated in a CLP-induced lung injury model
Drugbank entries Show/Hide entries for Lithium or IL1B
Comment The serum levels of the pro-inflammatory cytokines, TNF-alpha, IL-6, and IL-1beta decreased after administration of lithium in rats with CLP-induced lung injury.
Formal Description
Interaction-ID: 61561

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

IL6

in serum; if expression has been upregulated in a CLP-induced lung injury model
Drugbank entries Show/Hide entries for Lithium or IL6
Comment Administration of lithium to rats with CLP-induced lung injury increased the SOD activity. High SOD activity prevents the cell from oxidative stress damage.
Formal Description
Interaction-ID: 61562

drug/chemical compound

Lithium

increases_activity of

gene/protein

SOD

in lung tissue of a CLP-induced lung injury model
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Comment Rats with CLP-induced tissue injury showed dense inflammatory cell infiltrations with a diffuse and nodular form. Total obstructions were seen in the pulmonary vessels. Administration of lithium results in a decrease of inflammatory cell infiltration.
Formal Description
Interaction-ID: 61563

drug/chemical compound

Lithium

decreases_activity of

in lung tissue of a CLP-induced lung injury model
Drugbank entries Show/Hide entries for Lithium
Comment Rats with CLP-induced tissue injury showed dense inflammatory cell infiltrations with a diffuse and nodular form. Total obstructions were seen in the pulmonary vessels. Administration of lithium results in a decrease of inflammatory cell infiltration.
Formal Description
Interaction-ID: 61576

drug/chemical compound

Lithium

decreases_activity of

in lung tissue of a CLP-induced lung injury model
Drugbank entries Show/Hide entries for Lithium
Comment The serum levels of the pro-inflammatory cytokines, TNF-alpha, IL-6, and IL-1beta decreased after administration of lithium in rats with CLP-induced lung injury.
Formal Description
Interaction-ID: 61578

drug/chemical compound

Lithium

decreases_activity of

in serum; if expression of cytokines has been upregulated in a CLP-induced lung injury model
Drugbank entries Show/Hide entries for Lithium
Comment Administration of lithium to rats with CLP-induced lung injury decreased the level of 8-iso-prostaglandin F2alpha (8-ISO, 8-Isoprostane) in lung tissue.
Formal Description
Interaction-ID: 61580

drug/chemical compound

Lithium

decreases_quantity of

drug/chemical compound

8-Isoprostane

in lung tissue of a CLP-induced lung injury model
Drugbank entries Show/Hide entries for Lithium
Comment Administration of lithium to rats with CLP-induced lung injury increased the total levels of glutathione (GSH) in the lung tissues of rats.
Formal Description
Interaction-ID: 61583

drug/chemical compound

Lithium

decreases_quantity of

drug/chemical compound

Glutathione

in lung tissue of a CLP-induced lung injury model
Drugbank entries Show/Hide entries for Lithium or Glutathione
Comment Administration of lithium to rats with CLP-induced lung injury increased the SOD activity. High SOD activity prevents the cell from oxidative stress damage.
Formal Description
Interaction-ID: 61585

drug/chemical compound

Lithium

decreases_activity of

Drugbank entries Show/Hide entries for Lithium