General Information:

Id: 6,483 (click here to show other Interactions for entry)
Diseases: Lung disease
Homo sapiens
article/cited
Reference: Dennler S et al.(1998) Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene EMBO J. 17: 3091-3100 [PMID: 9606191]

Interaction Information:

Comment Overexpression of Smad7 leads to a 50% inhibition of TGFbeta-induced transcription of the CAGA box reporter construct. (CAGA boxes are the binding sites for SMAD3/4 complexes on target genes)
Formal Description
Interaction-ID: 61521

gene/protein

SMAD7

decreases_activity of

process

transforming growth factor beta receptor signaling pathway

in HepG2 cells