General Information:

Id: 6,483 (click here to show other Interactions for entry)
Diseases: Lung disease
Homo sapiens
Reference: Dennler S et al.(1998) Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene EMBO J. 17: 3091-3100 [PMID: 9606191]

Interaction Information:

Comment TGFbeta signaling results in SMAD2 and SMAD3 phosphorylation. SMAD2/3 form heteromeric complexes with SMAD4 and these complexes are translocated to the nucleus to induce the expression of target genes. (cited information)
Formal Description
Interaction-ID: 61518

increases_activity of