General Information:

Id: 6,481 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Reference: Folch J et al.(2015) The role of leptin in the sporadic form of Alzheimers disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin Life Sci. 140: 19-28 [PMID: 25998028]

Interaction Information:

Comment In the periphery, the fat mass participates in the regulation of glucose and insulin metabolism through the release of hormones in a bidirectional feedback loop, a mechanism called the adipoinsular axis. This axis links adipose tissue and pancreatic beta-cells via leptin and insulin, respectively.
Formal Description
Interaction-ID: 62244

tissue/cell line

adipose tissue

affects_activity of

through the adipoinsular axis