General Information:

Id: 647
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0003350 BV-2 cell
article
Reference: Ezzi SA et al.(2007) Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation J. Neurochem. 102: 170-178 [PMID: 17394546]

Interaction Information:

Comment Exposure of BV2 cells to either G93A SOD1 or oxidized WT SOD1 induced the expression of TNF-alpha and iNOS.
Formal Description
Interaction-ID: 3436

protein modification

SOD1-mod

increases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment Exposure of BV2 cells to either G93A SOD1 or oxidized WT SOD1 induced the expression of TNF-alpha; and iNOS.
Formal Description
Interaction-ID: 3437

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment Exposure of BV2 cells to either G93A SOD1 or oxidized WT SOD1 induced the expression of TNF-alpha and iNOS.
Formal Description
Interaction-ID: 3438

protein modification

SOD1-mod

increases_expression of

gene/protein

NOS2

Drugbank entries Show/Hide entries for NOS2
Comment Exposure of BV2 cells to either G93A SOD1 or oxidized WT SOD1 induced the expression of TNF-alpha and iNOS.
Formal Description
Interaction-ID: 3439

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

NOS2

Drugbank entries Show/Hide entries for NOS2