General Information:

Id: 646
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0001976 Neuro-2a cell
article
Reference: Ezzi SA et al.(2007) Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation J. Neurochem. 102: 170-178 [PMID: 17394546]

Interaction Information:

Comment Oxidation affects the misfolding and aggregation of WT SOD1 as well as mutant SOD1 (G93A).
Formal Description
Interaction-ID: 3425

increases_quantity of

phenotype

SOD1 protein aggregates

Comment Oxidation by H2O2 can cause misfolding of WT SOD1 with ensuing interaction with Hsp/Hsc70. Hsp/Hsc70 was co-immunoprecipitated with mutant G93A, oxidized WT SOD1, but not with non-oxidized WT SOD1.
Formal Description
Interaction-ID: 3426

protein modification

SOD1-mod

interacts (colocalizes) with

gene/protein

HSPA8

Drugbank entries Show/Hide entries for HSPA8
Comment Oxidation by H2O2 can cause misfolding of WT SOD1 with ensuing interaction with Hsp/Hsc70. Hsp/Hsc70 was co-immunoprecipitated with mutant G93A, oxidized WT SOD1, but not with non-oxidized WT SOD1.
Formal Description
Interaction-ID: 3428

gene/protein mutant

SOD1-p.G93A

interacts (colocalizes) with

gene/protein

HSPA8

Drugbank entries Show/Hide entries for HSPA8
Comment Oxidation by H2O2 can cause misfolding of WT SOD1 with ensuing interaction with Hsp/Hsc70. Hsp/Hsc70 was co-immunoprecipitated with mutant G93A, oxidized WT SOD1, but not with non-oxidized WT SOD1.
Formal Description
Interaction-ID: 3429

gene/protein

SOD1

NOT interacts (colocalizes) with

gene/protein

HSPA8

Drugbank entries Show/Hide entries for SOD1 or HSPA8
Comment Oxidized WT SOD1 can be conjugated to poly-ubiquitin. WT SOD1 in H2O2-treated cells was conjugated with multi-ubiquitin chain unlike WT SOD1 from untreated cells. The same phenomenon was observed with G93A mutant SOD1.
Formal Description
Interaction-ID: 3430

increases_ubiquitination/sumoylation of

protein modification

SOD1-mod

Comment Oxidized WT SOD1 can be conjugated to poly-ubiquitin. WT SOD1 in H2O2-treated cells was conjugated with multi-ubiquitin chain unlike WT SOD1 from untreated cells. The same phenomenon was observed with G93A mutant SOD1.
Formal Description
Interaction-ID: 3431

increases_ubiquitination/sumoylation of

gene/protein mutant

SOD1-p.G93A

Comment Oxidized WT-SOD1 interacts with chromogranin B (CgB). CgB was co-immunoprecipitated with either G93A SOD1 or oxidized WT SOD1, but not with intact WT SOD1.
Formal Description
Interaction-ID: 3432

protein modification

SOD1-mod

interacts (colocalizes) with

gene/protein

CHGB

Comment Oxidized WT-SOD1 interacts with chromogranin B (CgB). CgB was co-immunoprecipitated with either G93A SOD1 or oxidized WT SOD1, but not with intact WT SOD1.
Formal Description
Interaction-ID: 3433

gene/protein mutant

SOD1-p.G93A

interacts (colocalizes) with

gene/protein

CHGB

Comment Oxidized WT-SOD1 interacts with chromogranin B (CgB). CgB was co-immunoprecipitated with either G93A SOD1 or oxidized WT SOD1, but not with intact WT SOD1.
Formal Description
Interaction-ID: 3434

gene/protein

SOD1

NOT interacts (colocalizes) with

gene/protein

CHGB

Drugbank entries Show/Hide entries for SOD1