General Information:

Id: 6,456 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Viollet B et al.(2012) Cellular and molecular mechanisms of metformin: an overview Clin. Sci. 122: 253-270 [PMID: 22117616]

Interaction Information:

Comment Of particular note is the inhibition of IGF-1-induced mTOR activity by thiazolidinediones, another class of antidiabetic drugs which activate AMPK, indicating that activation of the kinase could further attenuate signalling pathways downstream insulin and/or IGF-1 receptors, particularly at the level of mTOR.
Formal Description
Interaction-ID: 61375

drug/chemical compound

Thiazolidinedione

decreases_activity of

gene/protein

IGF1

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