General Information:

Id: 645
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000007 HEK-293 cells
article
Reference: Ryder J et al.(2003) Divergent roles of GSK3 and CDK5 in APP processing Biochem. Biophys. Res. Commun. 312: 922-929 [PMID: 14651959]

Interaction Information:

Comment Both, GSK3beta and CDK5, are involved in APP processing. The data implicate these two kinases in the pathogenesis of Alzheimer's disease but in a divergent manner.
Formal Description
Interaction-ID: 3424

gene/protein

GSK3B

affects_processing of

gene/protein

APP

APP processed to amyloid beta peptide
Drugbank entries Show/Hide entries for GSK3B or APP
Comment Both, GSK3beta and CDK5, are involved in APP processing. The data implicate these two kinases in the pathogenesis of Alzheimer's disease but in a divergent manner.
Formal Description
Interaction-ID: 3427

gene/protein

CDK5

affects_processing of

gene/protein

APP

APP processed to amyloid beta peptide
Drugbank entries Show/Hide entries for CDK5 or APP
Comment Both, GSK3beta and CDK5, are involved in APP processing. The data implicate these two kinases in the pathogenesis of Alzheimer's disease but in a divergent manner.
Formal Description
Interaction-ID: 3446

gene/protein

GSK3B

affects_activity of

Drugbank entries Show/Hide entries for GSK3B
Comment Both, GSK3beta and CDK5, are involved in APP processing. The data implicate these two kinases in the pathogenesis of Alzheimer's disease but in a divergent manner.
Formal Description
Interaction-ID: 3447

gene/protein

CDK5

affects_activity of

Drugbank entries Show/Hide entries for CDK5
Comment Lithium acts through GSK3B to modulate APP metabolism and significantly reduces Abeta (amyloid beta peptide) production. The exact mechanism by which lithium modulates GSK3 activity is uncertain.
Formal Description
Interaction-ID: 3448

drug/chemical compound

Lithium

affects_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for Lithium or GSK3B
Comment Lithium acts through GSK3B to modulate APP metabolism and significantly reduces Abeta (amyloid beta peptide) production. The exact mechanism by which lithium modulates GSK3 activity is uncertain.
Formal Description
Interaction-ID: 3449

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

Amyloid beta peptide

Drugbank entries Show/Hide entries for Lithium
Comment Lithium acts through GSK3B to modulate APP metabolism and significantly reduces Abeta (amyloid beta peptide) production. The exact mechanism by which lithium modulates GSK3 activity is uncertain.
Formal Description
Interaction-ID: 41789

drug/chemical compound

Lithium

affects_activity of

Drugbank entries Show/Hide entries for Lithium