General Information:

Id: 6,438 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
streptozotocin-induced diabetic rat
article
Reference: Bahmani F et al.(2012) Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats Mol. Vis. 18: 439-448 [PMID: 22355255]

Interaction Information:

Comment Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity.
Formal Description
Interaction-ID: 60781

disease

Streptozocin-induced diabetes

increases_quantity of

drug/chemical compound

Advanced glycation end-product

in lens
Comment Some lens parameters, including glycated proteins, advanced glycation end products (AGEs), superoxide dismutase (SOD), and aldose reductase (AR) activities, were increased while some others, including soluble and total protein, glutathione (GSH) level, and catalase (CAT) activity, were decreased due to diabetes induction. After Gly treatment, all the above-named parameters had reverse changes except for the CAT activity.
Formal Description
Interaction-ID: 60787

drug/chemical compound

Glycine

decreases_quantity of

drug/chemical compound

Advanced glycation end-product

in lens
Drugbank entries Show/Hide entries for Glycine
Comment Glycine treatment significantly decreased the amount of serum glucose (Glc), serum AGEs, and glycated hemoglobin (HbA1c) in the diabetic rats.
Formal Description
Interaction-ID: 60793

drug/chemical compound

Glycine

decreases_quantity of

drug/chemical compound

Advanced glycation end-product

in blood serum
Drugbank entries Show/Hide entries for Glycine