General Information:

Id: 6,432 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Szeliga M and Obara-Michlewska M(2009) Glutamine in neoplastic cells: focus on the expression and roles of glutaminases Neurochem. Int. 55: 71-75 [PMID: 19428809]

Interaction Information:

Comment Glutamine (Gln) is engaged in synthesis of peptides, nucleotides and amino sugars. Moreover, it is a precursor of Glu, which is metabolized to such molecules as gamma-aminobutyrate, GSH, folic acid.
Formal Description
Interaction-ID: 61082

drug/chemical compound

Glutamate

affects_quantity of

drug/chemical compound

Glutathione

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Comment Glutathione (GSH) is an important product of Gln metabolism. It is a factor responsible for resistance of many tumors for chemo- and radiotherapy. Reducing of GSH levels resulted in decreased number of metastatic loci in mice livers inoculated with B16 melanoma cells. GSH depletion, resulting from Gln deprivation, decreased proliferation and enhanced chemosensitivity of neuroblastoma cells. On the other hand, introducing glutamine into diet may improve anticancer therapy, as was shown for rats bearing DMBA-induced mammary tumors. In these mice, glutaminase and enzymes involved in GSH metabolism were induced in the host and downregulated in tumor cells.
Formal Description
Interaction-ID: 61094

drug/chemical compound

Glutathione

affects_activity of

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