General Information:

Id: 642 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Klunk WE et al.(2001) Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci. 69: 1471-1484 [PMID: 11554609]

Interaction Information:

Comment Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and stained both plaques and tangles in post-mortem AD brain. An encouraging method for future PET imaging studies of brain amyloid deposits to identify potential patients appropriate for anti-amyloid drug therapy prior to the onset of symptoms when it would be most important to initiate treatment.
Formal Description
Interaction-ID: 3418

drug/chemical compound

Uncharged thioflavin-T derivative

interacts (colocalizes) with

gene/protein

Amyloid beta peptide