General Information:

Id: 6,387 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
review
Reference: Cetrullo S et al.(2015) mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management Crit. Rev. Eukaryot. Gene Expr. 25: 59-75 [PMID: 25955819]

Interaction Information:

Comment SIRT1 overexpression in neurons is associated with a reduction in mTOR protein levels and activity, thus providing a new SIRT1 negative modulation of mTOR signaling.
Formal Description
Interaction-ID: 61679

gene/protein

SIRT1

decreases_activity of

gene/protein

MTOR

if SIRT1 is overexpressed.
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