General Information:

Id: 6,387 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
review
Reference: Cetrullo S et al.(2015) mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management Crit. Rev. Eukaryot. Gene Expr. 25: 59-75 [PMID: 25955819]

Interaction Information:

Comment It has been demonstrated that AMPK does not directly phosphorylate SIRT1, but the effect of this kinase on lipid oxidation is to modify the NAD+/NADH ratio, thus modulating SIRT1 deacetylase activity. Some evidence indicates that the expression of Nampt (Nicotinamide phosphoribosyl-transferase), which is involved in the synthesis of NAD+ by the NAD+ salvage pathway, is induced by AMPK.
Formal Description
Interaction-ID: 61674

complex/PPI

AMPK

affects_activity of

gene/protein

SIRT1

via modifying the NAD+/NADH ratio.