General Information:

Id: 6,387 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
review
Reference: Cetrullo S et al.(2015) mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management Crit. Rev. Eukaryot. Gene Expr. 25: 59-75 [PMID: 25955819]

Interaction Information:

Comment Substrates / targets of Sirt1 are p53, PGC-1alpha, HIF1a and HIF2a, LXR (liver X receptor), SREB-Ps, FXR (farnesoid X receptor), NF-kappaB, PER2 (period circadian protein homolog 2), CRTC2 (CREB-regulated transcription coactivator 2), E2F1, and KU70.
Formal Description
Interaction-ID: 61643

gene/protein

SIRT1

affects_activity of

gene/protein

EPAS1