General Information:

Id: 6,387 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
review
Reference: Cetrullo S et al.(2015) mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management Crit. Rev. Eukaryot. Gene Expr. 25: 59-75 [PMID: 25955819]

Interaction Information:

Comment It has been shown that NAD+ increases in mammals during exercise, fasting, and caloric restriction, and the same conditions are associated with intensive Sirt1 activity.
Formal Description
Interaction-ID: 61626

environment

caloric restriction

increases_activity of

gene/protein

SIRT1