General Information:

Id: 6,387 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
review
Reference: Cetrullo S et al.(2015) mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management Crit. Rev. Eukaryot. Gene Expr. 25: 59-75 [PMID: 25955819]

Interaction Information:

Comment The NAD+ biosynthetic rate is crucial in Sirt1 regulation. Only in the presence of the cosubstrate NAD+ does the reaction lead to removal of actyl groups from an acetylated substrate, releasing nicotinamide, 2'-O-acetyl-ADP-ribose and the deacetylated target (e.g. histonic lysines).
Formal Description
Interaction-ID: 61617

drug/chemical compound

NAD+

affects_activity of

gene/protein

SIRT1