General Information:

Id: 6,387 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
review
Reference: Cetrullo S et al.(2015) mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management Crit. Rev. Eukaryot. Gene Expr. 25: 59-75 [PMID: 25955819]

Interaction Information:

Comment Sir2 hast seven orthologs (Sirt1-Sirt7) in mammals that are ubiquitously expressed in tissues and have different subcellular localizations and activities. While Sirt1, Sirt6, and Sirt7 lie mainly in the nucleus, Sirt3, Sirt4, and Sirt5 are mitochondrial protein and Sirt2 is found to act in the cytoplasm.
Formal Description
Interaction-ID: 61567

gene/protein

SIRT1

is localized in

cellular component

nucleus