General Information:

Id: 6,362 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Anastasiou D and Cantley LC(2012) Breathless cancer cells get fat on glutamine Cell Res. 3: 443-446 [PMID: 22212478]

Interaction Information:

Comment The dependence on glutamine for proliferation persists even under hypoxic conditions, against the prediction that limited activity of the respiratory chain should alleviate the need for anaplerosis. Cells cultured under hypoxia took up glutamine at higher rates than under normoxia and use it for lipid synthesis.
Formal Description
Interaction-ID: 59791

increases_transport of

drug/chemical compound


into the cell