General Information:

Id: 6,362 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Anastasiou D and Cantley LC(2012) Breathless cancer cells get fat on glutamine Cell Res. 3: 443-446 [PMID: 22212478]

Interaction Information:

Comment Under hypoxic conditions, which are frequently encountered in the tumor environment, pyruvate enters mitochondria at reduced rates. This is, in part, because hypoxia induces the stabilization of the transcription factor HIF-1a (hypoxia-inducible factor-1a). One of the transcriptional targets of HIF-1a is pyruvate dehydrogenase kinase 1 (PDK1), which limits conversion of pyruvate into acetyl-CoA in mitochondria by phosphorylating the E1 subunit of PDH and thus inactivating the enzyme. Limiting pyruvate entry into mitochondria will also reduce glucose-derived carbons available for acetyl-CoA and ultimately lipid synthesis.
Formal Description
Interaction-ID: 59786

increases_activity of



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