General Information:

Id: 635 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mammalia
ETNA cell; BTO:0004488 NSC-34 cell; BTO:0000932 neuroblastoma cell line
article
Reference: Crosio C et al.(2006) Bcl2a1 serves as a switch in death of motor neurons in amyotrophic lateral sclerosis Cell Death Differ. 13: 2150-2153 [PMID: 16710367]

Interaction Information:

Comment On the contrary, in neuronal cells stimulated with TNF-alpha, Bcl2a1 loses its antiapoptotic properties against cell death induced by G93A-SOD1 and becomes proapoptotic.
Formal Description
Interaction-ID: 3385

gene/protein

TNF

affects_activity of

gene/protein

BCL2A1

in neuronal cells
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Comment The overexpression of Bcl2a1 and G93A-SOD1 increases the level of cell death after exposure to TNF-alpha, a situation mimicking the condition of neuroinflammation occurring in ALS.
Formal Description
Interaction-ID: 3392

gene/protein

TNF

increases_activity of

process

neuron apoptotic process

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