General Information:

Id: 635
Diseases: Amyotrophic lateral sclerosis
Mammalia
ETNA cell; BTO:0004488 NSC-34 cell; BTO:0000932 neuroblastoma cell line
article
Reference: Crosio C et al.(2006) Bcl2a1 serves as a switch in death of motor neurons in amyotrophic lateral sclerosis Cell Death Differ. 13: 2150-2153 [PMID: 16710367]

Interaction Information:

Comment In motoneuronal cells expressing Bcl2a1 and either G93A-SOD1 or WT SOD1, Bcl2a1 upregulation is a protective, rather than detrimental consequence of the expression of toxic G93A-SOD1.
Formal Description
Interaction-ID: 3383

gene/protein

BCL2A1

decreases_activity of

Comment On the contrary, in neuronal cells stimulated with TNF-alpha, Bcl2a1 loses its antiapoptotic properties against cell death induced by G93A-SOD1 and becomes proapoptotic.
Formal Description
Interaction-ID: 3385

gene/protein

TNF

affects_activity of

gene/protein

BCL2A1

in neuronal cells
Drugbank entries Show/Hide entries for TNF
Comment The overexpression of Bcl2a1 and G93A-SOD1 increases the level of cell death after exposure to TNF-alpha, a situation mimicking the condition of neuroinflammation occurring in ALS.
Formal Description
Interaction-ID: 3392

gene/protein

TNF

increases_activity of

Drugbank entries Show/Hide entries for TNF
Comment On the contrary, in neuronal cells stimulated with TNF-alpha, Bcl2a1 loses its antiapoptotic properties against cell death induced by G93A-SOD1 and becomes proapoptotic.
Formal Description
Interaction-ID: 13861

gene/protein

BCL2A1

increases_activity of

in neuronal cells; after exposure to TNF-alpha