General Information:

Id: 6,302 (click here to show other Interactions for entry)
Diseases: Breast cancer - [OMIM]
Homo sapiens
L02 and HepG2 liver hepatocellular cells
article/cited
Reference: Zhang W et al.(2016) Tris(2-chloroethyl)phosphate-induced cell growth arrest via attenuation of SIRT1-independent PI3K/Akt/mTOR pathway J Appl Toxicol 36: 914-924 [PMID: 26378621]

Interaction Information:

Comment SIRT1 overexpression negatively regulated the mTOR pathway by the TSC1/2 complex in mouse embryonic fibroblasts and HeLa cells (cited information).
Formal Description
Interaction-ID: 60354

gene/protein

SIRT1

affects_activity of

complex/PPI

TSC1-TSC2 complex

in mouse embryonic fibroblasts and HeLa cells; if SIRT1 is overexpressed, resulting in a negative regulation the mTOR pathway.