General Information:

Id: 6,302 (click here to show other Interactions for entry)
Diseases: Breast cancer - [OMIM]
Homo sapiens
L02 and HepG2 liver hepatocellular cells
article/cited
Reference: Zhang W et al.(2016) Tris(2-chloroethyl)phosphate-induced cell growth arrest via attenuation of SIRT1-independent PI3K/Akt/mTOR pathway J Appl Toxicol 36: 914-924 [PMID: 26378621]

Interaction Information:

Comment SIRT1 overexpression negatively regulated the mTOR pathway by the TSC1/2 complex in mouse embryonic fibroblasts and HeLa cells (cited information). In other experiments SIRT1 potentially regulated mTOR signaling using a negative-feedback loop. SIRT1 overexpression can intensify its interaction with mTOR signaling, and then regulate cell metabolism, growth or survival. SIRT1 overexpression promoted cell survival through inhibiting mTOR signaling (cited information).
Formal Description
Interaction-ID: 60212

gene/protein

SIRT1

decreases_activity of

process

TOR signaling

in mouse embryonic fibroblasts and HeLa cells; if SIRT1 is overexpressed, via TSC1-TSC2 complex.