General Information:

Id: 6,302 (click here to show other Interactions for entry)
Diseases: Breast cancer - [OMIM]
Homo sapiens
L02 and HepG2 liver hepatocellular cells
article/cited
Reference: Zhang W et al.(2016) Tris(2-chloroethyl)phosphate-induced cell growth arrest via attenuation of SIRT1-independent PI3K/Akt/mTOR pathway J Appl Toxicol 36: 914-924 [PMID: 26378621]

Interaction Information:

Comment SIRT1 overexpression not only promoted mitotic entry of liver cells, cell growth and proliferation, but also protected cells from apoptosis through activation of the PTEN/PI3K/Akt pathway (cited information).
Formal Description
Interaction-ID: 60211

gene/protein

SIRT1

increases_activity of

process

PTEN/PI3K/AKT signaling

if SIRT1 is overexpressed, resulting in a protection of the cells from apoptosis.