General Information:

Id: 6,302 (click here to show other Interactions for entry)
Diseases: Breast cancer - [OMIM]
Homo sapiens
L02 and HepG2 liver hepatocellular cells
article/cited
Reference: Zhang W et al.(2016) Tris(2-chloroethyl)phosphate-induced cell growth arrest via attenuation of SIRT1-independent PI3K/Akt/mTOR pathway J Appl Toxicol 36: 914-924 [PMID: 26378621]

Interaction Information:

Comment TCEP (Tris(2-chloroethyl)phosphate) reduced the cell viability of L02 and HepG2 cells, induced the cell growth arrest, upregulated mRNA and protein levels of SIRT1, and attenuated the SIRT1-independent PI3K/Akt/mTOR pathway. The growth arrest of the L02 and HepG2 cells were aggravated after inhibiting the SIRT1 expression with EX-527. The findings above suggested that TCEP induced the cell growth arrest of L02 and HepG2 cells via attenuation of the SIRT1-independent PI3K/Akt/mTOR pathway.
Formal Description
Interaction-ID: 60209

gene/protein

SIRT1

NOT affects_activity of

process

PI3K/AKT/TOR signaling

in L02 and HepG2 cells