General Information:

Id: 6,301 (click here to show other Interactions for entry)
Diseases: Angioimmunoblastic T-Cell lymphoma
Cancer
Cutaneous T-cell lymphoma
Peripheral T-cell leukemia / lymphoma
Homo sapiens
peripheral T-cell lymphoma
article/cited
Reference: Quesada AE et al.(2014) Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-kappaB pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options Int J Clin Exp Pathol 7: 8732-8739 [PMID: 25674239]

Interaction Information:

Comment A patient with AITL (Angioimmunoblastic T-Cell Lymphoma, a rare, aggressive (fast-growing) form of peripheral T-cell lymphoma (PTCL)) showed a remarkable durable response using a combination of conventional CHOP and bortezomib. All seven markers (p-mTOR (Ser 2448), p-Akt (Ser 473), p-NF-kappaBp65 (Ser 536), COX2, Bcl-2, FASN, and Sirt1) were highly expressed, indicating expressing constitutive activation of the mTORC2/NF-kappaB pathway in this patient who responded remarkably well to an NF-kappaB antagonist.
Formal Description
Interaction-ID: 60191

disease

Angioimmunoblastic T-Cell lymphoma

increases_expression of

gene/protein

SIRT1