General Information:

Id: 6,301 (click here to show other Interactions for entry)
Diseases: Angioimmunoblastic T-Cell lymphoma
Cancer
Cutaneous T-cell lymphoma
Peripheral T-cell leukemia / lymphoma
Homo sapiens
peripheral T-cell lymphoma
article/cited
Reference: Quesada AE et al.(2014) Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-kappaB pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options Int J Clin Exp Pathol 7: 8732-8739 [PMID: 25674239]

Interaction Information:

Comment Vorinostat is able to dephosphorylate Akt on serine 473 by increasing the activity of protein phosphatase 1 (PP1), to downregulate SIRT1 mRNA, and to reduce Sirt1 deacetylase activity (cited information).
Formal Description
Interaction-ID: 60156

drug/chemical compound

Vorinostat

decreases_activity of

gene/protein

SIRT1

of SIRT1 mRNA and Sirt1 deacetylase activity.
Drugbank entries Show/Hide entries for Vorinostat