General Information:

Id: 6,301 (click here to show other Interactions for entry)
Diseases: Angioimmunoblastic T-Cell lymphoma
Cancer
Cutaneous T-cell lymphoma
Peripheral T-cell leukemia / lymphoma
Homo sapiens
peripheral T-cell lymphoma
article/cited
Reference: Quesada AE et al.(2014) Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-kappaB pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options Int J Clin Exp Pathol 7: 8732-8739 [PMID: 25674239]

Interaction Information:

Comment Sirt1, reportedly deacetylates Akt and thereby, promotes phosphatidylinositol (3,4,5)-triphosphate binding to Akt and participates in its activation (cited information).
Formal Description
Interaction-ID: 60139

gene/protein

SIRT1

increases_activity of

gene/protein

AKT1

via promoting phosphatidylinositol (3,4,5)-triphosphate binding to Akt.
Drugbank entries Show/Hide entries for AKT1