General Information:

Id: 6,301 (click here to show other Interactions for entry)
Diseases: Angioimmunoblastic T-Cell lymphoma
Cancer
Cutaneous T-cell lymphoma
Peripheral T-cell leukemia / lymphoma
Homo sapiens
peripheral T-cell lymphoma
article/cited
Reference: Quesada AE et al.(2014) Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-kappaB pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options Int J Clin Exp Pathol 7: 8732-8739 [PMID: 25674239]

Interaction Information:

Comment 10 PTCL patients demonstrated nuclear and cytoplasmic staining (high expression) for p-Akt (Ser 473) and p-mTOR (Ser 2448) corresponding to mTORC 2, and all cases showed strong, diffuse nuclear translocation for p-NF-kappaBp65 (Ser 536). All ten cases also showed cytoplasmic staining for IGF-1R (Tyr1165/1166). In addition, high expression in the tumor cells (>50%) of nuclear Sirt1, and cytoplasmic COX-2 and FASN were detected in PTCL cells in 7, 9 and 8 out of 10 cases, respectively.
Formal Description
Interaction-ID: 60088

disease

Peripheral T-cell leukemia / lymphoma

increases_expression of

gene/protein

SIRT1

Pattern of staining: Nuclear.