General Information:

Id: 6,275 (click here to show other Interactions for entry)
Diseases: Glioblastoma
Homo sapiens
BTO:0002035 U-251 MG cell
Reference: Jiang H et al.(2009) Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells J. Exp. Ther. Oncol. 8: 25-33 [PMID: 19827268]

Interaction Information:

Comment Resveratrol (trans-3,4', 5-trihydroxystilbene) is a naturally occurring polyphenolic compound that has antiinflammatory, antioxidant, neuroprotective properties and acts as a chemopreventive agent. Resveratrol causes cell cycle arrest and induces apoptotic cell death in various types of cancer cells. In the current studies, the effect of resveratrol on phosphoinositide kinase-3 (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway was examined in human U251 glioma cells. Resveratrol decreased both the expression and phosphorylation of Akt. Inhibitors of PI3K (LY294002) and Akt (SH-6) enhanced resveratrol-induced lactate dehydrogenase (LDH) release and caspase-3 activation.
Formal Description
Interaction-ID: 58704

drug/chemical compound


increases_activity of


increased lactate dehydrogenase release

in U251 glioma cells
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