General Information:

Id: 6,275 (click here to show other Interactions for entry)
Diseases: Glioblastoma
Homo sapiens
BTO:0002035 U-251 MG cell
article
Reference: Jiang H et al.(2009) Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells J. Exp. Ther. Oncol. 8: 25-33 [PMID: 19827268]

Interaction Information:

Comment Resveratrol (trans-3,4', 5-trihydroxystilbene) is a naturally occurring polyphenolic compound that has antiinflammatory, antioxidant, neuroprotective properties and acts as a chemopreventive agent. Resveratrol causes cell cycle arrest and induces apoptotic cell death in various types of cancer cells. In the current studies, the effect of resveratrol on phosphoinositide kinase-3 (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway was examined in human U251 glioma cells. Resveratrol decreased both the expression and phosphorylation of Akt. Inhibitors of PI3K (LY294002) and Akt (SH-6) enhanced resveratrol-induced LDH release and caspase-3 activation.
Formal Description
Interaction-ID: 58636

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

AKT1

in U251 glioma cells
Drugbank entries Show/Hide entries for Resveratrol or AKT1
Comment Resveratrol (trans-3,4', 5-trihydroxystilbene) is a naturally occurring polyphenolic compound that has antiinflammatory, antioxidant, neuroprotective properties and acts as a chemopreventive agent. Resveratrol causes cell cycle arrest and induces apoptotic cell death in various types of cancer cells. In the current studies, the effect of resveratrol on phosphoinositide kinase-3 (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway was examined in human U251 glioma cells. Resveratrol decreased both the expression and phosphorylation of Akt. Inhibitors of PI3K (LY294002) and Akt (SH-6) enhanced resveratrol-induced lactate dehydrogenase (LDH) release and caspase-3 activation.
Formal Description
Interaction-ID: 58700

drug/chemical compound

Resveratrol

increases_activity of

gene/protein

CASP3

in U251 glioma cells
Drugbank entries Show/Hide entries for Resveratrol or CASP3
Comment Resveratrol (trans-3,4', 5-trihydroxystilbene) is a naturally occurring polyphenolic compound that has antiinflammatory, antioxidant, neuroprotective properties and acts as a chemopreventive agent. Resveratrol causes cell cycle arrest and induces apoptotic cell death in various types of cancer cells. In the current studies, the effect of resveratrol on phosphoinositide kinase-3 (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway was examined in human U251 glioma cells. Resveratrol decreased both the expression and phosphorylation of Akt. Inhibitors of PI3K (LY294002) and Akt (SH-6) enhanced resveratrol-induced lactate dehydrogenase (LDH) release and caspase-3 activation.
Formal Description
Interaction-ID: 58704

drug/chemical compound

Resveratrol

increases_activity of

phenotype

increased lactate dehydrogenase release

in U251 glioma cells
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol reduced phosphorylation of ribosomal protein S6 and the mTOR inhibitor rapamycin further enhanced resveratrol-induced cell death.
Formal Description
Interaction-ID: 58711

drug/chemical compound

Resveratrol

decreases_phosphorylation of

gene/protein

RPS6

in U251 glioma cells
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol induces dose-dependent decrease of cyclin D1 expression.
Formal Description
Interaction-ID: 58713

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

CCND1

in U251 glioma cells
Drugbank entries Show/Hide entries for Resveratrol or CCND1
Comment Resveratrol decreases the activation of pro-survival PI3K/Akt signaling pathway and inhibition of PI3K/Akt further enhances resveratrol-induced apoptosis.
Formal Description
Interaction-ID: 58714

drug/chemical compound

Resveratrol

decreases_activity of

in U251 glioma cells
Drugbank entries Show/Hide entries for Resveratrol