General Information:

Id: 623
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
C57BL/6 GPAT1 knockout mouse
article
Reference: Collison LW et al.(2008) Glycerol-3-phosphate acyltransferase-1 regulates murine T-lymphocyte proliferation and cytokine production. Am. J. Physiol. 295 [PMID: 18971390]

Interaction Information:

Comment Spleen weight is significantly reduced by 14 % in GPAT1 knockout mice.
Formal Description
Interaction-ID: 3314

gene/protein

GPAM

affects_quantity of

tissue/cell line

spleen

Comment Within the splenic T-lymphocyte population in GPAT1 knockout mice, the CD4+ T-lymphocytes are significantly increased by 20 % while the CD8+ population is not affected.
Formal Description
Interaction-ID: 3359

gene/protein

GPAM

affects_quantity of

tissue/cell line

helper T-lymphocyte

in spleen
Comment In GPAT1 knockout mice the Th-1 (interleukin 2 and interferon-gamma) cytokine secretion is reduced, and Th-2 (interleukin 4 and interleukin 10) secretion is increased.
Formal Description
Interaction-ID: 3361

gene/protein

GPAM

affects_expression of

gene/protein

IL2

Drugbank entries Show/Hide entries for IL2
Comment In GPAT1 knockout mice the membrane lipid composition of T-lymphocytes differs from wild-type mice, the mass of all the major glycerophospholipid species (phosphatidic acid, phosphatidylethanolamine, phosphatidylinositol, phospatidylserine, and phosphatidylcholine) is significantly reduced in GPAT1 knockout mice.
Formal Description
Interaction-ID: 3362

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Phosphatidate

in T-lymphocyte membrane
Comment In GPAT1 knockout mice the membrane lipid composition of T-lymphocytes differs from wild-type mice, the mass of all the major glycerophospholipid species (phosphatidic acid, phosphatidylethanolamine, phosphatidylinositol, phospatidylserine, and phosphatidylcholine) is significantly reduced in GPAT1 knockout mice.
Formal Description
Interaction-ID: 3364

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Phosphatidylethanolamine

in T-lymphocyte membrane
Drugbank entries Show/Hide entries for
Comment In GPAT1 knockout mice the membrane lipid composition of T-lymphocytes differs from wild-type mice, the mass of all the major glycerophospholipid species (phosphatidic acid, phosphatidylethanolamine, phosphatidylinositol, phospatidylserine, and phosphatidylcholine) is significantly reduced in GPAT1 knockout mice.
Formal Description
Interaction-ID: 3365

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Phosphatidylinositol

in T-lymphocyte membrane
Comment In GPAT1 knockout mice the membrane lipid composition of T-lymphocytes differs from wild-type mice, the mass of all the major glycerophospholipid species (phosphatidic acid, phosphatidylethanolamine, phosphatidylinositol, phospatidylserine, and phosphatidylcholine) is significantly reduced in GPAT1 knockout mice.
Formal Description
Interaction-ID: 3366

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Phosphatidylserine

in T-lymphocyte membrane
Drugbank entries Show/Hide entries for
Comment In GPAT1 knockout mice the membrane lipid composition of T-lymphocytes differs from wild-type mice, the mass of all the major glycerophospholipid species (phosphatidic acid, phosphatidylethanolamine, phosphatidylinositol, phospatidylserine, and phosphatidylcholine) is significantly reduced in GPAT1 knockout mice.
Formal Description
Interaction-ID: 3367

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Phosphatidylcholine

in T-lymphocyte membrane
Comment In GPAT1 knockout mice the sphingomyelin and cardiolipin content of the membranes of T-lymphocytes is not changed.
Formal Description
Interaction-ID: 3368

gene/protein

GPAM

NOT affects_quantity of

drug/chemical compound

Sphingomyelin

in T-lymphocyte membrane
Comment In GPAT1 knockout mice the sphingomyelin and cardiolipin content of the membranes of T-lymphocytes is not changed.
Formal Description
Interaction-ID: 3369

gene/protein

GPAM

NOT affects_quantity of

drug/chemical compound

Cardiolipin

in T-lymphocyte membrane
Drugbank entries Show/Hide entries for
Comment Protein mass was significantly reduced in T-lymphocytes of GPAT1 knockout mice.
Formal Description
Interaction-ID: 3370

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Protein

in T-lymphocyte
Comment Cholesterol mass is not affected in splenic T-lyphocytes from GPAT1 knockout mice.
Formal Description
Interaction-ID: 3371

gene/protein

GPAM

NOT affects_quantity of

drug/chemical compound

Cholesterol

in T-lymphocyte
Drugbank entries Show/Hide entries for
Comment The splenic T-lymphocyte membrane fatty acid composition is altered in GPAT1 knockout mice, palmitate (16:0) is significantly decreased while stearate (18:0) and arachidonate (20:4, n-6) are significantly increased.
Formal Description
Interaction-ID: 3372

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Palmitic acid

in T-lymphocyte
Drugbank entries Show/Hide entries for
Comment The splenic T-lymphocyte membrane fatty acid composition is altered in GPAT1 knockout mice, palmitate (16:0) is significantly decreased while stearate (18:0) and arachidonate (20:4, n-6) are significantly increased.
Formal Description
Interaction-ID: 3373

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Stearic acid

in T-lymphocyte
Drugbank entries Show/Hide entries for
Comment The splenic T-lymphocyte membrane fatty acid composition is altered in GPAT1 knockout mice, palmitate (16:0) is significantly decreased while stearate (18:0) and arachidonate (20:4, n-6) are significantly increased.
Formal Description
Interaction-ID: 3374

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Arachidonic acid

in T-lymphocyte
Drugbank entries Show/Hide entries for
Comment Arachidonate is the substrate for eicosanoid production. GPAT1 knockout increases T-lymphocyte eicosanoid production (prostaglandin E2 35 % and leukotriene B4 85 %).
Formal Description
Interaction-ID: 3375

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Prostaglandin E2

in T-lymphocyte
Comment Arachidonate is the substrate for eicosanoid production. GPAT1 knockout increases T-lymphocyte eicosanoid production (prostaglandin E2 35 % and leukotriene B4 85 %).
Formal Description
Interaction-ID: 3377

gene/protein

GPAM

affects_quantity of

drug/chemical compound

Leukotriene B4

in T-lymphocyte
Comment Activation-induced apoptosis in T-lymphocytes was significantly increased in GPAT1 knockout mice in response to CD3-CD28 stimulation.
Formal Description
Interaction-ID: 3381

gene/protein

GPAM

affects_activity of

in T-lymphocyte
Comment GPAT1 knockout has a profound effect on T-lymphocyte membrane lipid composition, cytokine production, apoptosis, and eicosanoid production, thus GPAT1 can regulate T-lymphocyte function.
Formal Description
Interaction-ID: 3382

gene/protein

GPAM

affects_activity of

Comment GPAT1 may be a novel target for preventing or treating insulin resistance, diabetes, and hepatic steatosis, however caution should be taken when designing these strategies because GPAT1 also affects the immune function.
Formal Description
Interaction-ID: 3384

gene/protein

GPAM

affects_activity of

process

immune response

Comment The changes in young GPAT1 knockout splenic T-lymphocytes are similar to defects commonly seen in T-lymphocytes from aged rodents, which further underscores the significance of GPAT-1 in T-lymphocyte function.
Formal Description
Interaction-ID: 3386

gene/protein

GPAM

affects_activity of

Comment In GPAT1 knockout mice the Th-1 (interleukin 2 and interferon-gamma) cytokine secretion is reduced, and Th-2 (interleukin 4 and interleukin 10) secretion is increased.
Formal Description
Interaction-ID: 12544

gene/protein

GPAM

affects_expression of

gene/protein

IFNG

Drugbank entries Show/Hide entries for IFNG
Comment In GPAT1 knockout mice the Th-1 (interleukin 2 and interferon-gamma) cytokine secretion is reduced, and Th-2 (interleukin 4 and interleukin 10) secretion is increased.
Formal Description
Interaction-ID: 12545

gene/protein

GPAM

affects_expression of

gene/protein

IL4

Comment In GPAT1 knockout mice the Th-1 (interleukin 2 and interferon-gamma) cytokine secretion is reduced, and Th-2 (interleukin 4 and interleukin 10) secretion is increased.
Formal Description
Interaction-ID: 12546

gene/protein

GPAM

affects_expression of

gene/protein

IL10

Comment Within the splenic T-lymphocyte population in GPAT1 knockout mice, the CD4+ T-lymphocytes are significantly increased by 20 % while the CD8+ population is not affected.
Formal Description
Interaction-ID: 12549

gene/protein

GPAM

NOT affects_quantity of

tissue/cell line

cytotoxic T-lymphocyte

in spleen
Comment GPAT1 may be a novel target for preventing or treating insulin resistance, diabetes, and hepatic steatosis, however caution should be taken when designing these strategies because GPAT1 also affects the immune function.
Formal Description
Interaction-ID: 12559

gene/protein

GPAM

affects_activity of

Comment GPAT1 may be a novel target for preventing or treating insulin resistance, diabetes, and hepatic steatosis, however caution should be taken when designing these strategies because GPAT1 also affects the immune function.
Formal Description
Interaction-ID: 12560

gene/protein

GPAM

affects_activity of

disease

Insulin resistance

Comment GPAT1 may be a novel target for preventing or treating insulin resistance, diabetes, and hepatic steatosis, however caution should be taken when designing these strategies because GPAT1 also affects the immune function.
Formal Description
Interaction-ID: 12561

gene/protein

GPAM

affects_activity of

disease

Fatty liver disease, nonalcoholic