General Information:

Id: 6,212 (click here to show other Interactions for entry)
Diseases: Metabolic
Homo sapiens
article
Reference: Kofman AE et al.(2013) Transcriptional analysis of histone deacetylase family members reveal similarities between differentiating and aging spermatogonial stem cells Stem Cell Rev 9: 59-64 [PMID: 22729928]

Interaction Information:

Comment When SSCs are exposed to the lifespan-enhancing drug rapamycin in vivo, the resultant HDAC gene expression patterns are opposite of those seen in the differentiating and aging SSCs, with increased Hdac2, Hdac6, and Sirt1 and decreased Hdac8, Hdac9, and Sirt4.
Formal Description
Interaction-ID: 58881

drug/chemical compound

Rapamycin

increases_expression of

gene/protein

SIRT1

in both differentiating and aging spermatogonial stem cells (SSCs)