General Information:

Id: 6,212 (click here to show other Interactions for entry)
Diseases: Metabolic
Homo sapiens
article
Reference: Kofman AE et al.(2013) Transcriptional analysis of histone deacetylase family members reveal similarities between differentiating and aging spermatogonial stem cells Stem Cell Rev 9: 59-64 [PMID: 22729928]

Interaction Information:

Comment In both differentiating and aging spermatogonial stem cells (SSCs) the expression of Sirt4 increases, while the expression of Hdac2, Hdac6, and Sirt1 decreases.
Formal Description
Interaction-ID: 58878

tissue/cell line

spermatogonial stem cell

decreases_expression of

gene/protein

SIRT1

in both differentiating and aging spermatogonial stem cells