General Information:

Id: 6,212
Diseases: Metabolic
Homo sapiens
article
Reference: Kofman AE et al.(2013) Transcriptional analysis of histone deacetylase family members reveal similarities between differentiating and aging spermatogonial stem cells Stem Cell Rev 9: 59-64 [PMID: 22729928]

Interaction Information:

Comment In both differentiating and aging spermatogonial stem cells (SSCs) the expression of Sirt4 increases, while the expression of Hdac2, Hdac6, and Sirt1 decreases.
Formal Description
Interaction-ID: 57899

tissue/cell line

spermatogonial stem cell

increases_expression of

gene/protein

SIRT4

in both differentiating and aging spermatogonial stem cells
Comment In both differentiating and aging spermatogonial stem cells (SSCs) the expression of Sirt4 increases, while the expression of Hdac2, Hdac6, and Sirt1 decreases. Findings suggest that HDACs important for stem cell maintenance and oxidative capacity are downregulated as adult stem cells differentiate or age.
Formal Description
Interaction-ID: 58876

tissue/cell line

spermatogonial stem cell

decreases_expression of

gene/protein

HDAC2

in both differentiating and aging spermatogonial stem cells
Drugbank entries Show/Hide entries for HDAC2
Comment In both differentiating and aging spermatogonial stem cells (SSCs) the expression of Sirt4 increases, while the expression of Hdac2, Hdac6, and Sirt1 decreases. Findings suggest that HDACs important for stem cell maintenance and oxidative capacity are downregulated as adult stem cells differentiate or age.
Formal Description
Interaction-ID: 58877

tissue/cell line

spermatogonial stem cell

decreases_expression of

gene/protein

HDAC6

in both differentiating and aging spermatogonial stem cells
Drugbank entries Show/Hide entries for HDAC6
Comment In both differentiating and aging spermatogonial stem cells (SSCs) the expression of Sirt4 increases, while the expression of Hdac2, Hdac6, and Sirt1 decreases.
Formal Description
Interaction-ID: 58878

tissue/cell line

spermatogonial stem cell

decreases_expression of

gene/protein

SIRT1

in both differentiating and aging spermatogonial stem cells
Comment When SSCs are exposed to the lifespan-enhancing drug rapamycin in vivo, the resultant HDAC gene expression patterns are opposite of those seen in the differentiating and aging SSCs, with increased Hdac2, Hdac6, and Sirt1 and decreased Hdac8, Hdac9, and Sirt4.
Formal Description
Interaction-ID: 58879

drug/chemical compound

Rapamycin

increases_expression of

gene/protein

HDAC2

in both differentiating and aging spermatogonial stem cells (SSCs)
Drugbank entries Show/Hide entries for HDAC2
Comment When SSCs are exposed to the lifespan-enhancing drug rapamycin in vivo, the resultant HDAC gene expression patterns are opposite of those seen in the differentiating and aging SSCs, with increased Hdac2, Hdac6, and Sirt1 and decreased Hdac8, Hdac9, and Sirt4.
Formal Description
Interaction-ID: 58880

drug/chemical compound

Rapamycin

increases_expression of

gene/protein

HDAC6

in both differentiating and aging spermatogonial stem cells (SSCs)
Drugbank entries Show/Hide entries for HDAC6
Comment When SSCs are exposed to the lifespan-enhancing drug rapamycin in vivo, the resultant HDAC gene expression patterns are opposite of those seen in the differentiating and aging SSCs, with increased Hdac2, Hdac6, and Sirt1 and decreased Hdac8, Hdac9, and Sirt4.
Formal Description
Interaction-ID: 58881

drug/chemical compound

Rapamycin

increases_expression of

gene/protein

SIRT1

in both differentiating and aging spermatogonial stem cells (SSCs)
Comment When SSCs are exposed to the lifespan-enhancing drug rapamycin in vivo, the resultant HDAC gene expression patterns are opposite of those seen in the differentiating and aging SSCs, with increased Hdac2, Hdac6, and Sirt1 and decreased Hdac8, Hdac9, and Sirt4.
Formal Description
Interaction-ID: 58882

drug/chemical compound

Rapamycin

decreases_expression of

gene/protein

HDAC8

in both differentiating and aging spermatogonial stem cells (SSCs)
Drugbank entries Show/Hide entries for HDAC8
Comment When SSCs are exposed to the lifespan-enhancing drug rapamycin in vivo, the resultant HDAC gene expression patterns are opposite of those seen in the differentiating and aging SSCs, with increased Hdac2, Hdac6, and Sirt1 and decreased Hdac8, Hdac9, and Sirt4.
Formal Description
Interaction-ID: 58883

drug/chemical compound

Rapamycin

decreases_expression of

gene/protein

HDAC9

in both differentiating and aging spermatogonial stem cells (SSCs)
Drugbank entries Show/Hide entries for HDAC9
Comment When SSCs are exposed to the lifespan-enhancing drug rapamycin in vivo, the resultant HDAC gene expression patterns are opposite of those seen in the differentiating and aging SSCs, with increased Hdac2, Hdac6, and Sirt1 and decreased Hdac8, Hdac9, and Sirt4.
Formal Description
Interaction-ID: 58884

drug/chemical compound

Rapamycin

decreases_expression of

gene/protein

SIRT4

in both differentiating and aging spermatogonial stem cells (SSCs)