General Information:

Id: 62
Diseases: Parkinson disease
Parkinson disease 2, autosomal recessive juvenile - [OMIM]
Rattus norvegicus
BTO:0000143 substantia nigra
article
Reference: Lo Bianco C et al.(2004) Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinsons disease Proc. Natl. Acad. Sci. U.S.A. 101 [PMID: 15576511]

Interaction Information:

Comment Animals expressing alpha-synuclein mutant A30P show loss of neurons in the substantia nigra.
Formal Description
Interaction-ID: 192

gene/protein mutant

SNCA-p.A30P

increases_activity of

process

neuron death

in substantia nigra
Comment Parkin prevents SNCA-A30P induced neurodegeneration in the substantia nigra.
Formal Description
Interaction-ID: 1008

gene/protein

PARK2

decreases_activity of

process

neuron death

in substantia nigra