General Information:

Id: 615
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0001176 endothelial cell
article
Reference: Giraudo E et al.(1998) Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells. J. Biol. Chem. 273 [PMID: 9705358]

Interaction Information:

Comment TNF-alpha up-regulates in a dose- and time-dependent manner the expression and the function of vascular endothelial growth factor receptor-2 (VEGFR-2) as well as the expression of its co-receptor neuropilin-1 in human endothelium.
Formal Description
Interaction-ID: 3249

gene/protein

TNF

increases_quantity of

gene/protein

KDR

Drugbank entries Show/Hide entries for TNF or KDR
Comment TNF-alpha up-regulates in a dose- and time-dependent manner the expression and the function of vascular endothelial growth factor receptor-2 (VEGFR-2) as well as the expression of its co-receptor neuropilin-1 in human endothelium.
Formal Description
Interaction-ID: 3250

gene/protein

TNF

increases_expression of

gene/protein

NRP1

Drugbank entries Show/Hide entries for TNF or NRP1
Comment TNF-alpha does not up-regulate the expression of vascular endothelial growth factor receptor-1 (VEGFR-1, FLT1) in human endothelium.
Formal Description
Interaction-ID: 3251

gene/protein

TNF

NOT increases_expression of

gene/protein

FLT1

Drugbank entries Show/Hide entries for TNF or FLT1
Comment Mithramycin at 1 and 10 nmol inhibits the TNF-alpha-induced expression of VEGFR-2, suggesting that Sp1 binding sites in the promoter are involved in up-regulation of VEGFR-2 molecules.
Formal Description
Interaction-ID: 3252

drug/chemical compound

Mithramycin

decreases_expression of

gene/protein

KDR

Drugbank entries Show/Hide entries for KDR
Comment TNF-alpha enhances the endothelial cell migration and the wound healing triggered by VEGF-A165.
Formal Description
Interaction-ID: 3267

gene/protein

TNF

increases_activity of

Drugbank entries Show/Hide entries for TNF
Comment TNF-alpha enhances the endothelial cell migration and the wound healing triggered by VEGF-A165.
Formal Description
Interaction-ID: 3270

gene/protein

TNF

increases_activity of

process

wound healing

Drugbank entries Show/Hide entries for TNF