General Information:

Id: 614 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Kang DE et al.(2002) Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis Cell 110: 751-762 [PMID: 12297048]

Interaction Information:

Comment PS1 strongly promotes GSK3B-dependent sequential phosphorylation of Thr41, Ser37, and Ser33, starting presumably from a GSK3B-independent priming event on S45.
Formal Description
Interaction-ID: 3307

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

CTNNB1

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