General Information:

Id: 614 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Kang DE et al.(2002) Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis Cell 110: 751-762 [PMID: 12297048]

Interaction Information:

Comment Presenilin functions as a scaffold that rapidly couples beta-catenin (CTNNB1) phosphorylation through two sequential kinase activities independent of the Wnt-regulated Axin/CK1alpha complex.
Formal Description
Interaction-ID: 3288

gene/protein

PSEN1

affects_phosphorylation of

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1