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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	614 (click here to show other Interactions for entry)
Diseases:	Alzheimer disease - [OMIM]
Organism:	Homo sapiens
Publication type:	article
Reference:	Kang DE et al.(2002) Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis Cell 110: 751-762 [PMID: 12297048]

Interaction Information:

Comment	PS1 acts as a negative regulator of the Wnt/beta-catenin signaling pathway.
Formal Description Interaction-ID: 3248	gene/protein PSEN1 decreases_activity of process canonical Wnt signaling pathway

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