General Information:

Id: 614 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Kang DE et al.(2002) Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis Cell 110: 751-762 [PMID: 12297048]

Interaction Information:

Comment PS1 acts as a negative regulator of the Wnt/beta-catenin signaling pathway.
Formal Description
Interaction-ID: 3248

gene/protein

PSEN1

decreases_activity of

process

canonical Wnt signaling pathway

Comment Wnt signaling rapidly decreased the steady-state levels of P-33/37/41 (=phosphorylated at positions 33, 37, and 41) but not P-45 (=S45-phosphorylated) beta-catenin resulting in accumulation of cytosolic beta-catenin.
Formal Description
Interaction-ID: 3294

process

canonical Wnt signaling pathway

decreases_quantity of

protein modification

CTNNB1-phosSer33Ser37Thr41

(= sequentially phosphorylated CTNNB1 at sites 33,37,41)
Comment Wnt signaling rapidly decreased the steady-state levels of P-33/37/41 (=phosphorylated at positions 33, 37, and 41) but not P-45 (=S45-phosphorylated) beta-catenin resulting in accumulation of cytosolic beta-catenin.
Formal Description
Interaction-ID: 3299

process

canonical Wnt signaling pathway

NOT decreases_quantity of

protein modification

CTNNB1-phosSer45

Comment beta-Catenin is part of the canonical Wnt/beta-catenin signaling pathway.
Formal Description
Interaction-ID: 45038

gene/protein

CTNNB1

increases_activity of

process

canonical Wnt signaling pathway

Drugbank entries Show/Hide entries for CTNNB1