General Information:

Id: 6,145 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Patterson AJ et al.(2012) Hypoxia-derived oxidative stress mediates epigenetic repression of PKCepsilon gene in foetal rat hearts Cardiovasc. Res. 93: 302-310 [PMID: 22139554]

Interaction Information:

Comment Hypoxia produced a time-dependent increase in ROS production in H9c2 cells and foetal hearts that was blocked by ROS scavengers N-acetyl-cysteine or tempol. In accordance, N-acetyl-cysteine and tempol, but not apocynin, inhibited the hypoxic effect and restored PKCepsilon protein and mRNA expression to the control values in foetal hearts and H9c2 cells.
Formal Description
Interaction-ID: 57527

increases_quantity of

drug/chemical compound

Reactive oxygen species