General Information:

Id: 6,145 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
article
Reference: Patterson AJ et al.(2012) Hypoxia-derived oxidative stress mediates epigenetic repression of PKCepsilon gene in foetal rat hearts Cardiovasc. Res. 93: 302-310 [PMID: 22139554]

Interaction Information:

Comment In H9c2 cells and foetal hearts, hypoxia caused nuclear accumulation of HIF-1alpha, which was inhibited by 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and 2-methoxy estradiol. The HIF-1alpha inhibitors had no significant effect on hypoxia-induced PKCepsilon mRNA repression.
Formal Description
Interaction-ID: 57526

increases_quantity of

gene/protein

HIF1A

in nucleus
Drugbank entries Show/Hide entries for HIF1A