General Information:

Id: 6,145 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
article
Reference: Patterson AJ et al.(2012) Hypoxia-derived oxidative stress mediates epigenetic repression of PKCepsilon gene in foetal rat hearts Cardiovasc. Res. 93: 302-310 [PMID: 22139554]

Interaction Information:

Comment Hypoxia induced in vivo to pregnant rats, ex vivo to isolated foetal rat hearts, and in vitro in the rat embryonic ventricular myocyte cell line H9c2 resulted in a comparable decrease in PKCepsilon protein and mRNA abundance in foetal hearts and H9c2 cells, which was associated with a significant increase in CpG methylation of the SP1-binding sites at the PKCepsilon promoter.
Formal Description
Interaction-ID: 57483

decreases_expression of

gene/protein

PRKCE

via epigenetic repression